TeXMacs

User preferences

Your settings are saved in $HOME/.TeXmacs directory. Sometimes this may get corrupted and lead to weird issues; just delete this directory an restart TeXmacs. You will of course lose your settings, so you need to add them back.

Python

Set python path in /Applications/TeXmacs.app/Contents/Resources/share/TeXmacs/plugins/python/progs

(define (python-command) "/opt/homebrew/Caskroom/miniforge/base/bin/python")

PDF output

Set PDF version in Edit -> Preferences -> Convert -> Pdf -> Pdf version number. This setting is saved in $HOME/.TeXmacs/system/preferences.scm file.